朱红艳

作者:金飞     日期:2023-10-11   点击数:2829  

师资介绍


姓名:朱红艳

性别:女

民族:汉族

出生年月:1978.06.23

职称:教授

学历:博士

职务:药物制剂系党支部书记

                          

研究方向:1.核酸药物递释系统;2.仿生药物递送系统。

主持或参加科研项目(课题)

1.      江苏省自然科学基金面上项目,BK20201443,靶向调控肿瘤转移前微环境的工程化“外泌体影”仿生递释系统研究,2020/7-2023/610万元,在研,主持 

2.      国家自然科学基金青年基金项目,81202467,胞内触发释药的仿生型siRNA自组装胶束纳米复合物的构建、抗肿瘤转移作用及细胞内药物动力学研究,2013/1-2015/1223万元,已结题,主持 

3.      江苏省青年科学基金项目BK2012232靶向肿瘤血管生成的仿生型小核酸药物递释系统研究2012/7-2015/720万元,已结题,主持 

4.      江苏省教育厅高校自然科学研究面上项目11KJB350004谷胱甘肽触发释放的智能型siRNA复合载体(穿膜肽Tat-壳聚糖-量子点)的构建及其抗肿瘤活性研究2011/01-2014/123万元,已结题,主持 

5.      江苏省高校自然科学研究指导性项目06KJD310150南瓜多糖对链脲菌素诱导的胰岛损伤的保护作用及机制研究,2007/01-2008/121万元,已结题,主持。

6.      南通市课题,Exosome@CBSA 仿生 siRNA 递送系统的构建及其抗乳腺癌术后转移作用研究,2018.07-2020.06,项目编号:JC20180245万元。

代表性研究成果和学术奖励情况

第一作者和通讯作者论文,专利

(1)             Lixing Xu, Xiao Du, Yao Zhou, Xinyu Cao, Ying Shen, Hongyan Zhu,* and Haiqin Huang*. Polyaspartic Acid-Stabilized CaCO3‑Containing In Situ Hydrogel for Protection and Treatment of Gastric Ulcer. Mol. Pharmaceutics. 2023, 20(4):2105-2118.

(2)            Haiqin Huang, Lanlan Shao, Yan Chen, Weili Han, Yao Zhou, Tianqing Liu, Jinhua Gu,* and Hongyan Zhu*. Sequential Dual Delivery System Based on siCOX-2-Loaded Gold Nanostar and Thermal-Sensitive Liposomes Overcome Hypoxia Mediated Multidrug Resistance in Tumors. Mol. Pharmaceutics. 2022, 19(7):2390-2405.

(3)              Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Hongyun Li, Hongyan Zhu* and Tianqing Liu*. Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer. Journal of Nanobiotechnology. 2022, 20:359.

(4)          Haiqin Huang, Lanlan Shao, Yan Chen, Lan Tang, Tianqing Liu, Junxu Li, and Hongyan Zhu*. Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer. Bioeng Transl Med. 2021, 7(2):e10284.

(5)                 Shengyu Zhang, Ye Gan, Lanlan Shao, Tianqing Liu, Danyi Wei, Yanyan Yu,* Hongwei Guo,* and Hongyan Zhu*. Virus Mimetic Shell-Sheddable Chitosan Micelles for siVEGF Delivery and FRET-Traceable Acid-Triggered Release. ACS Appl. Mater. Interfaces. 2020, 12, 53598−53614.IF=9.229

(6)              Liuwan ZhaoChunyan GuYe GanLanlan ShaoHongwei ChenHongyan Zhu*. Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis. J Control Release. 2020, 318, 1-15.IF=9.776

(7)                  Hongyan Zhu,Weili HanYe GanQiaofeng LiXiaolan LiLanlan ShaoDan Zhu* and Hongwei Guo*. Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma. Pharmaceutics 2019, 11(12), 683IF=6.321

(8)                 Yanyan Yu, Min Zhou, Wei Zhang, Lei Huang, Dandan Miao, Hongyan Zhu*, Gaoxing Su*. Rattle-Type Gold Nanorods/Porous-SiO2 Nanocomposites as Near-Infrared Light-Activated Drug Delivery Systems for Cancer Combined Chemo-Photothermal Therapy. Mol. Pharmaceutics. 2019,16(5) 1929-1938IF=4.939

(9)                   Su GMiao DYu YZhou MJiao PCao XYan BZhu H*. Mesoporous silica-coated gold nanostars with drug payload for combined chemo-photothermal cancer therapy. J Drug Target. 2019 Feb; 27(2):201-210. IF=5.121

(10)                Shengyu Zhang, Yanjun Liu, Ye Gan, Nanqing Qiu, Yueqing GuHongyan Zhu*. Conjugates of TAT and folate with DOX-loaded chitosan micelles offer effective intracellular delivery ability. Pharm Dev Technol. 2019, 24(2):253-261.IF=3.133

(11)                Shengyu Zhang, Liuwan Zhao, Nanqin Qiu, Yanjun Liu, Bohui Xu, Hongyan Zhu*, On the hypoxic tumor targeting ability of two chitosan micelles loaded with oil-soluble CdSe quantum dots. Pharm Dev Technol. 2018, 23(1):87-95.IF=3.133

(12)                 Hongyan Zhu*, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu and Gaoxing Su*, Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment. Int J Mol Sci. 2017, 18(10):2029.IF=5.923

(13)               Fei Liu, Yuan Sun, Chen Kang, Hongyan Zhu*. Pegylated drug delivery systems: from design to biomedical applications. Nano Life. 2016, 6(3, 4):1642002 (1-11).

(14)             Bohui Xu, Yubin Wang, Hongyan Zhu*. Mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: Preparation and pharmacokinetics in beagle dogs. Pharmazie. 2016 71(2):76-83. IF=1.267

(15)                Hongyan Zhu, Shengyu Zhang, Yongling, Guoliang Meng, Yu Yang, Wei Zhang*. pH-responsive hybrid quantum dots for targeting hypoxic tumor siRNA delivery. J Control Release. 2015, 220(Pt A):529-544. IF=9.776

(16)                 Hongyan Zhu, Guangtong Chen, Guoliang Meng Jiliang Xu*. Characterization of pumpkin polysaccharides and protective effects on streptozotocin-damaged islet cells. Chin J Nat Med. 2015, 13(3):199-207. IF=3.000

(17)                 Hongyan Zhu, JingPing Zhu, AiMei Xie, Yong Lin, BeiBei Zhang, YiFei Wang, Wei Zhang*.Visible quantum-dot-based targeted siRNA delivery for HIF-1α gene silencing. J. Drug Del. Sci. Tech. 2014, 24 (5): 445-451.IF=3.981

(18)        Hongyan Zhu, Jie Cao, Sisi Cui, Zhiyu Qian, Yueqing Gu*. Enhanced tumor targeting and antitumor efficacy via hydroxycamptothecin-encapsulated folate-modified N-succinyl-N-octyl chitosan micelles. J Pharm Sci. 2013, 102 (4):1318-1332. IF=3.534

(19)                 Hongyan Zhu, Fei Liu, Jing Guo, Jianpeng Xue, Zhiyu Qian, Yueqing Gu*. Folate-modified chitosan micelles with enhanced tumor targeting evaluated by near infrared imaging system. Carbohydrate Polymers. 2011, 86(3):1118-1129. IF=9.381

(20)                 Jie Cao#Hongyan Zhu#, Dawei Deng, Bing Xue, Liping Tang, Didel Mahounga, Zhiyu Qian, Yueqing Gu*, In vivo NIR imaging with PbS quantum dots entrapped in biodegradable micelles. Journal of Biomedical Materials Research Part A. 2012: 100A: 958-968. IF=4.396

(21)                 程紫婷,姚珂,刘婉婉,许伯慧,朱红艳*, 紫杉醇温敏脂质体与siRNA金纳米星载药系统的构建与表征中国药科大学学报. 2017, 48(4):444-45.

(22)                 朱红艳,  朱景平,  谢爱梅,  袁静,  花烨,  张伟*. 肿瘤靶向高分子碲化镉量子点复合纳米粒的制备及其表征药学学报. 2014, 49 (10): 1457 -1465.

(23)                 刘婉婉,张胜喻,杨彧,朱红艳*. 具有肿瘤靶向及穿膜效应的壳聚糖胶束的制备中国药科大学学报. 2015, 46(5): 561-567.

(24)                 周瑶,曹欣雨,周佳敏,朱红艳*. 口服维生素C脂质体的制备及其稳定性研究南通大学学报(医学版). 2020, 40(5): 1-3.

(25)                 发明专利:朱红艳许伯慧陈忠平一种仿生siRNA胶束纳米复合物及应用专利号:ZL 2015 1 0189351.6,授权日:2018.07.24.

(26)                 朱红艳,赵刘碗,韩伟莉复合siRNA纳米载体及其制备方法和应用专利号:201810990330.8

(27)                 已经转让的专利:朱红艳谢爱梅杨池张贝贝王逸飞一种基于量子点的多功能纳米siRNA载体系统的制备及应用专利号:ZL 2014 1 0087972.9,转让时间:2020年,转让经费:4万元。

(28)                 朱红艳,赵刘碗韩伟莉光热材料和外泌体介导的化疗药组成的药物及其用途申请号:2019101129258, 实审发文号:2019042800173150.